DolceraWiki - User contributions [en]

File:All Patent Analysis sheet.xls

2009-08-18T14:38:00Z

Manmohang:

Choline Bitartarate

2009-08-18T14:34:04Z

Manmohang: /* Patent Analysis Sheets */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 444)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Choline_bitartrate.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt composition matrix.xls|Click here]]''' for Composition matrix showing all the ingredients used along with Choline Bitartarate.

===Patent Analysis Sheets===

*'''[[Media:All Patent Analysis sheet.xls|Click here for all Patents spread sheet-444 ON Targets]]'''

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Choline Bitartarate

2009-08-18T14:29:25Z

Manmohang: /* Search Strategy */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 444)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Choline_bitartrate.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt composition matrix.xls|Click here]]''' for Composition matrix showing all the ingredients used along with Choline Bitartarate.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Choline Bitartarate

2009-08-18T14:25:07Z

Manmohang: /* Search Strategy */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits ([[Media:625 records.xls|Unique Records 444]])'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Choline_bitartrate.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt composition matrix.xls|Click here]]''' for Composition matrix showing all the ingredients used along with Choline Bitartarate.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

File:Cbt composition matrix.xls

2009-08-18T13:33:37Z

Manmohang:

Choline Bitartarate

2009-08-18T13:33:13Z

Manmohang: /* Choline Bitartarate containing compositions */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Choline_bitartrate.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt composition matrix.xls|Click here]]''' for Composition matrix showing all the ingredients used along with Choline Bitartarate.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Choline Bitartarate

2009-08-18T13:19:15Z

Manmohang: /* Action of Choline bitartrate containing Compositions */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Choline_bitartrate.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

File:Choline bitartrate.mm

2009-08-18T13:18:34Z

Manmohang:

Choline Bitartarate

2009-08-18T12:29:25Z

Manmohang: /* Choline Bitartarate containing compositions */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
| 
| 
|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
| 
| 
| 
| 
| 
| 
|x
| 
| 
|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|x
|-
|}

*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Choline Bitartarate

2009-08-18T12:13:28Z

Manmohang: /* Choline Bitartarate containing compositions */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|US20040005368A1
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|US20040191294A1
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|US20060121158A1
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|US5626849A
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|US5904948A
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|WO2006052231A1
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|US20050171034A1
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|US20060241077A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|US20070065456A1
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|US20070248696A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|US20080317868A1
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|US4497800A
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|US4499076A
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|US4837219A
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|US5437880A
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|WO1994015488A2
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|US20050208191A1
| 
| 
|align = "center"|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|align = "center"|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|WO2005087018A1
| 
| 
| 
| 
| 
| 
|align = "center"|x
| 
| 
|align = "center"|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|align = "center"|x
|-
|}

*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Choline Bitartarate

2009-08-18T12:05:35Z

Manmohang: /* Choline Bitartarate containing compositions */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
[[Image:CBT Image.jpg|Right|250px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
*Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. [http://www.chemicalregister.com/D_-_Choline_Bitartrate/Suppliers/pid56388.htm Source]
*The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. [http://www.ncbi.nlm.nih.gov/pubmed/14972364 Source]

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
* For 2 patent / publications Assignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====

<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*[[Click here for Composition components matrix showing all the ingredients used along with Choline Bitartarate.]]
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|US20040005368A1
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|US20040191294A1
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|US20060121158A1
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|US5626849A
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|US5904948A
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|WO2006052231A1
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|US20050171034A1
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|US20060241077A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|US20070065456A1
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|US20070248696A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|US20080317868A1
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|US4497800A
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|US4499076A
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|US4837219A
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|US5437880A
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|WO1994015488A2
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|US20050208191A1
| 
| 
|align = "center"|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|align = "center"|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|WO2005087018A1
| 
| 
| 
| 
| 
| 
|align = "center"|x
| 
| 
|align = "center"|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|align = "center"|x
|-
|}

*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Click here for Composition components matrix showing all the ingredients used along with Choline Bitartarate.

2009-08-18T12:04:16Z

Manmohang:

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Beverage / liquid / Drink'''
|-
|align = "center" bgcolor = "#CCFFCC"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|-
|US20040005368A1
| 
| 
| 
| 
| 
| 
| 
|align = "center"|x
|Caffeine, Green Tea
| 
| 
|Oxygen uptake enhancing substance.
|-
|US20040191294A1
| 
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
| 
|Milk or milk-based products
|-
|US20060121158A1
| 
|align = "center"|x
| 
| 
| 
| 
|align = "center"|x
|align = "center"|x
|align = "center"|x
|align = "center"|x
| 
|Flavanol
|-
|US5626849A
| 
|align = "center"|x
| 
| 
|gamma-linolenic acid
|align = "center"|x
| 
| 
| 
| 
| 
|L-carnitine
|-
|US5904948A
| 
| 
|Maltodextrin
| 
| 
|align = "center"| 
|align = "center"|x
|Whey , milk or vegetable
| 
|align = "center"|x
| 
| 
|-
|WO2006052231A1
|leucine, isoleucine, valine and arginine.
| 
|align = "center"|x
| 
| 
| 
|align = "center"|x
| 
| 
| 
| 
| 
|-
|US20050171034A1
|N-acetyl-cysteine
|Alpha-lipoic acid
| 
| 
| 
| 
|Zn
| 
| 
|A, B, C, E
| 
|Betaine
|-
|US20060241077A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
| 
|Uridine or its derivative
|-
|US20070065456A1
| 
|Green tea extract
| 
|Taurine
| 
|Wasabia japonica, Silybum marianum and Cynara scolymus.
|Mn, Se Zn
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|-
|US20070248696A1
| 
| 
| 
| 
| 
| 
| 
| 
| 
|B1,B5, B6, B12,folic acid
| 
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract
|-
|US20080317868A1
| 
| 
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
| 
| 
|Nucleotide fraction
|-
|US4497800A
| 
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|-
|US4499076A
|Essential AA<nowiki>’</nowiki>S
| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"|x
|align = "center"| 
|align = "center"| 
|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
| 
|align = "center"|x
|-
|US4837219A
|L-Tyrosine, L-Phenylalanime, L-Leucine
| 
| 
| 
| 
| 
|Zn and Cu
| 
| 
| 
| 
|align = "center"|x
|-
|US5437880A
| 
|align = "center"|x
|Digestible saccharide
| 
| 
| 
| 
| 
| 
|A B, C, D, E and K .
| 
|Carotenoids
|-
|WO1994015488A2
| 
|align = "center"|x
|align = "center"|x
|choline Bitartrate
| 
| 
| 
| 
| 
| 
| 
|Neuromuscular function enhancer
|-
|align = "center" bgcolor = "#FFCC99" colspan = "13"|'''Foodstuff'''
|-
|US20050208191A1
| 
| 
|align = "center"|x
| 
| 
| 
|Fe, Zn, Cu, I ,
| 
| 
|align = "center"|x
|Sesame seed paste Sesame seed
|Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk
|-
|WO2005087018A1
| 
| 
| 
| 
| 
| 
|align = "center"|x
| 
| 
|align = "center"|x
|Wheat flour, roasted peanut paste, sesame seed, soybean flour
|align = "center"|x
|-
|}

Choline Bitartarate

2009-08-18T11:48:36Z

Manmohang: /* Overview */

Choline Bitartarate

2009-08-18T11:11:13Z

Manmohang: /* Top Assignees */

Choline Bitartarate

2009-08-18T11:09:29Z

Manmohang: /* Choline Bitartarate containing compositions */

Choline Bitartarate

2009-08-18T09:46:55Z

Manmohang: /* Overview */

Choline Bitartarate

2009-08-18T07:53:53Z

Manmohang: /* Overview */

File:CBT Image.jpg

2009-08-18T07:43:29Z

Manmohang:

Choline Bitartarate

2009-08-18T07:43:17Z

Manmohang: /* Overview */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
[[Image:CBT Image.jpg|Right|200px|thumb|'''Structure of Choline bitartrate''' [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6900#Synonyms Source]]]
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*[[Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.

2009-08-18T06:29:26Z

Manmohang:

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|''' '''
|bgcolor = "#FFCC99"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant.'''
|align = "center" bgcolor = "#CCFFCC"|'''Betaine'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Carotenoids'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Electrolytes'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Flavanol'''
|align = "center" bgcolor = "#CCFFCC"|'''Green tea extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''low-caloric sweetener'''
|align = "center" bgcolor = "#CCFFCC"|'''milk or milk-based products'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Nucleotide fraction'''
|align = "center" bgcolor = "#CCFFCC"|'''Oxygen uptake enhancing substance'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|align = "center" bgcolor = "#CCFFCC"|'''Polyols'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''pyridoxal-5-phosphate'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Taurine'''
|align = "center" bgcolor = "#CCFFCC"|'''Turmeric extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Uridine or its derivative'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat alpha amylase'''
|align = "center" bgcolor = "#CCFFCC"|'''Whole wheat'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat germ'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030082168%22.PGNR.&OS=DN/20030082168&RS=DN/20030082168 US20030082168A1]
|align = "center"|''' '''
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|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|Conjugated linoleic acid
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|Momordica charantia.
|align = "center"|''' '''
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|align = "center"|'''x'''
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|align = "center"|'''x'''
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|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''2'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|''' '''
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|align = "center"|Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate.
|align = "center"|''' '''
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|align = "center"|'''x'''
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|-
|align = "center" bgcolor = "#FFCC99"|'''3'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040082536%22.PGNR.&OS=DN/20040082536&RS=DN/20040082536 US20040082536A1]
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|align = "center"|Iron, iodine, magnesium, zinc, selenium, copper, chromium, potassium
|align = "center"|''' '''
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|align = "center"| A, C, D, E, K, B1, B2, B6, B12 and biotin.
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''4'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
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|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''5'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|N-acetyl-cysteine
|align = "center"|Alpha-lipoic acid
|align = "center"|'''x'''
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|align = "center"|zinc methionate
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|A, B, C, E, pyridoxal-5-phosphate
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''6'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|
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|align = "center"|'''x'''
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|align = "center"|Iron, zinc, copper, iodine and magnesium.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|'''x'''
|align = "center"|Sesame seed paste Sesame seed
|-
|align = "center" bgcolor = "#FFCC99"|'''7'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|
|align = "center"|'''x'''
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|-
|align = "center" bgcolor = "#FFCC99"|'''8'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|
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|-
|align = "center" bgcolor = "#FFCC99"|'''9'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Wasabia japonica, Silybum marianum and Cynara scolymus.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Manganese, selenium taurine, zinc,
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''10'''
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|align = "center"|
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|B1,B5, B6, B12,folic acid
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''11'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center" bgcolor = "#FFCC99"|'''12'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center" bgcolor = "#FFCC99"|'''13'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Essential amino acids
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''14'''
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|align = "center"|L-Tyrosine, L-Phenylalanime, L-Leucine
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|Zinc and Copper
|align = "center"|''' '''
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|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''15'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5215750.PN.&OS=PN/5215750&RS=PN/5215750 US5215750A]
|align = "center"|L-glutamine
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''16'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Digestible saccharide
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|A B, C, D, E and K .
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''17'''
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|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"| gamma-linolenic acid
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''18'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5719133.PN.&OS=PN/5719133&RS=PN/5719133 US5719133A]
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''19'''
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Maltodextrin
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Whey protein, milk protein, vegetable protein
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''20'''
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2004050876&F=0 WO1994015488A2]
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|choline Bitartrate
|align = "center"|''' '''
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|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
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|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2004050876&F=0 WO2005087018A1]
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|wheat flout, roasted peanut paste, sesame seed, soybean flour
|-
|align = "center" bgcolor = "#FFCC99"|'''22'''
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2004050876&F=0 WO2006052231A1]
|align = "center"|leucine, isoleucine, valine and arginine.
|align = "center"|''' '''
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|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
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|-
|}

Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.

2009-08-18T06:27:34Z

Manmohang:

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|''' '''
|bgcolor = "#FFCC99"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant.'''
|align = "center" bgcolor = "#CCFFCC"|'''Betaine'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Carotenoids'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Electrolytes'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Flavanol'''
|align = "center" bgcolor = "#CCFFCC"|'''Green tea extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''low-caloric sweetener'''
|align = "center" bgcolor = "#CCFFCC"|'''milk or milk-based products'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Nucleotide fraction'''
|align = "center" bgcolor = "#CCFFCC"|'''Oxygen uptake enhancing substance'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|align = "center" bgcolor = "#CCFFCC"|'''Polyols'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''pyridoxal-5-phosphate'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Taurine'''
|align = "center" bgcolor = "#CCFFCC"|'''Turmeric extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Uridine or its derivative'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat alpha amylase'''
|align = "center" bgcolor = "#CCFFCC"|'''Whole wheat'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat germ'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220030082168%22.PGNR.&OS=DN/20030082168&RS=DN/20030082168 US20030082168A1]
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|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|Conjugated linoleic acid
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|Momordica charantia.
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''2'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''3'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040082536%22.PGNR.&OS=DN/20040082536&RS=DN/20040082536 US20040082536A1]
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|Iron, iodine, magnesium, zinc, selenium, copper, chromium, potassium
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"| A, C, D, E, K, B1, B2, B6, B12 and biotin.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|''' '''
|-
|align = "center" bgcolor = "#FFCC99"|'''4'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|''' '''
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|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|
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|align = "center"|Digestible saccharide
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Choline Bitartarate

2009-08-18T05:52:27Z

Manmohang: /* White space analysis */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====Choline Bitartarate containing compositions====
*[[Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.

2009-08-18T05:40:00Z

Manmohang:

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|bgcolor = "#FFCC99"|'''Patent/Publication No.'''
|align = "center" bgcolor = "#CCFFCC"|'''Amino acids'''
|align = "center" bgcolor = "#CCFFCC"|'''Antioxidant.'''
|align = "center" bgcolor = "#CCFFCC"|'''Betaine'''
|align = "center" bgcolor = "#CCFFCC"|'''Carbohydrates / Sugars'''
|align = "center" bgcolor = "#CCFFCC"|'''Carotenoids'''
|align = "center" bgcolor = "#CCFFCC"|'''Energy Source / Enhancer'''
|align = "center" bgcolor = "#CCFFCC"|'''Electrolytes'''
|align = "center" bgcolor = "#CCFFCC"|'''Fatty Acids / A lipid Source'''
|align = "center" bgcolor = "#CCFFCC"|'''Flavanol'''
|align = "center" bgcolor = "#CCFFCC"|'''Green tea extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Herbal Extracts'''
|align = "center" bgcolor = "#CCFFCC"|'''low-caloric sweetener'''
|align = "center" bgcolor = "#CCFFCC"|'''milk or milk-based products'''
|align = "center" bgcolor = "#CCFFCC"|'''Minerals'''
|align = "center" bgcolor = "#CCFFCC"|'''Nucleotide fraction'''
|align = "center" bgcolor = "#CCFFCC"|'''Oxygen uptake enhancing substance'''
|align = "center" bgcolor = "#CCFFCC"|'''Others'''
|align = "center" bgcolor = "#CCFFCC"|'''Polyols'''
|align = "center" bgcolor = "#CCFFCC"|'''Proteins'''
|align = "center" bgcolor = "#CCFFCC"|'''pyridoxal-5-phosphate'''
|align = "center" bgcolor = "#CCFFCC"|'''Stimulant'''
|align = "center" bgcolor = "#CCFFCC"|'''Taurine'''
|align = "center" bgcolor = "#CCFFCC"|'''Turmeric extract'''
|align = "center" bgcolor = "#CCFFCC"|'''Uridine or its derivative'''
|align = "center" bgcolor = "#CCFFCC"|'''Vitamins'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat alpha amylase'''
|align = "center" bgcolor = "#CCFFCC"|'''Whole wheat'''
|align = "center" bgcolor = "#CCFFCC"|'''Wheat germ'''
|align = "center" bgcolor = "#CCFFCC"|'''Vegetable Sources'''
|-
|US20030082168A1
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|Conjugated linoleic acid
|align = "center"|''' '''
|align = "center"|'''x'''
|align = "center"|Momordica charantia.
|align = "center"|''' '''
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|align = "center"|'''x'''
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|US20040005368A1
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|align = "center"|''' '''
|align = "center"|Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|'''x'''
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|-
|US20040082536A1
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|align = "center"|Iron, iodine, magnesium, zinc, selenium, copper, chromium, potassium
|align = "center"|''' '''
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|align = "center"| A, C, D, E, K, B1, B2, B6, B12 and biotin.
|align = "center"|''' '''
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|-
|US20040191294A1
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|-
|US20050171034A1
|align = "center"|N-acetyl-cysteine
|align = "center"|Alpha-lipoic acid
|align = "center"|'''x'''
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|align = "center"|zinc methionate
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|''' '''
|align = "center"|A, B, C, E, pyridoxal-5-phosphate
|align = "center"|''' '''
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|align = "center"|''' '''
|align = "center"|''' '''
|-
|US20050208191A1
|align = "center"|
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|align = "center"|'''x'''
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|align = "center"|Iron, zinc, copper, iodine and magnesium.
|align = "center"|''' '''
|align = "center"|''' '''
|align = "center"|'''x'''
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|align = "center"|'''x'''
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|align = "center"|'''x'''
|align = "center"|'''x'''
|align = "center"|Sesame seed paste Sesame seed
|-
|US20060121158A1
|align = "center"|
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|-
|US20060241077A1
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|align = "center"|Wasabia japonica, Silybum marianum and Cynara scolymus.
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|align = "center"|Manganese, selenium taurine, zinc,
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|align = "center"|B1,B5, B6, B12,folic acid
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|align = "center"|Essential amino acids
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|align = "center"|Calcium pantothenate, nicotinic acid amide, biotin, folic acid
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|align = "center"|L-Tyrosine, L-Phenylalanime, L-Leucine
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|align = "center"|Digestible saccharide
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|align = "center"|A B, C, D, E and K .
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|US5626849A
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|align = "center"| gamma-linolenic acid
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|US5719133A
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|WO1994015488A2
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|align = "center"|choline Bitartrate
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|align = "center"|wheat flout, roasted peanut paste, sesame seed, soybean flour
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|WO2006052231A1
|align = "center"|leucine, isoleucine, valine and arginine.
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File:Cbt Non Patent Analysis sheet.xls

2009-08-18T05:30:24Z

Manmohang:

File:Other than cbt ingredients.xls

2009-08-18T05:29:34Z

Manmohang:

File:Cbt Patent Analysis sheet.xls

2009-08-18T05:28:48Z

Manmohang:

File:Cbt containing compositions.xls

2009-08-18T05:27:36Z

Manmohang:

File:Choline bitartarate updated.jpeg

2009-08-18T05:26:21Z

Manmohang:

Choline Bitartarate

2009-08-18T05:25:30Z

Manmohang: /* White space analysis */

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====White space analysis====
*[[Click here for Composition components matrix showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

File:CBT pie chart.jpg

2009-08-18T05:24:38Z

Manmohang:

File:CBT IP Trend.jpg

2009-08-18T05:24:19Z

Manmohang:

File:CBT TOP assignee.jpg

2009-08-18T05:23:58Z

Manmohang:

Choline Bitartarate

2009-08-18T05:21:28Z

Manmohang:

==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]

* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.

'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.

'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.

==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

* Years: From 1836 - To April 18, 2009.

{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}

===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]

====IP activity over the years====

* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.

[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]

====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]

====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.

[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]

====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>

====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids. 2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}

====White space analysis====
*[[Click here for table showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.

===Patent Analysis Sheets===

*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''

* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}

*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''

==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''

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2009-08-18T05:00:28Z

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| valign = "top" |

=== Dashboard ===
* [http://client.dolcera.com/dashboard/dashboard.html?workfilegroup_id=27 Automotive dashboard - live]
** [[Automotive Dashboard Screenshots|Screenshots only]]
* [http://client.dolcera.com/dashboard/dashboard.html?workfile_id=54 WiMAX dashboard - live]
** [[WiMAX Dashboard Screenshots|Screenshots only]]
* [http://www.dolcera.com/ipmapdemo/rfid_model.swf RFID dashboard]
|-
| valign = "top" |

=== IPMap ===
* [http://dolcera.com/client/d8r3/hairloss_map.htm Alopecia/Hair loss IPMap]
* [[Markush Structure Search Sample]]
==== Study: In re Bilski Impact ====
* [[In re Bilski Impact assessed from US PAIR Information]]
* [[In re Bilski 35 USC § 101 Rejections - Patent Application Analysis]]
| valign = "top" |

=== IPMap ===
* [http://www.dolcera.com/ipmapdemo/satellite_antenna/ipmap.html Satellite Antenna IPMap]
* [http://www.dolcera.com/ipmapdemo/rfid/ipmap.html RFID IPMap]
* [http://www.dolcera.com/ipmapdemo/multimodal_apps/ipmap.html Multimodal Applications IPMap]
* [http://www.dolcera.com/ipmapdemo/Invalidation_US4825448.htm Invalidation Claim Map Sample]
|-
|}

== Business and Information Research Services ==
{| style="border:1px solid #AAA; background:#E9E9E9;width:100%" align="center"
|-
! style="background:lightgrey" valign=top width=50%|
===Life Sciences and Chemistry===
! style="background:lightgrey" valign=top width=50%|
===Technology===
|-
| valign=top |
* [[Diabetes products and services]]
* [[Osteoporosis]]
* [[Oral Diabetes Drugs]]
* [[Ureteral Stent]]
* [[Premium Coffee Consumers Market Segmentation|Premium Coffee - Market Positioning]]
* [[Dolcera's Poster on Industrial Biotechnology|Industrial biotechnology]]
* [[OTC products for acne treatment]]
| valign=top |
* [[4G wireless technology developments]]
* [[HDTV in the US]]
* [http://www.dolcera.com/ipmapdemo/innovation_explorer/innovation_explorer.html Household robotics Innovation Explorer]
* [[Web video]]
* [[OLED Mobile Phones Market Research and Analysis Report]] | ([http://www.viddler.com/explore/dolcera/videos/6/ Video])
* [[Virtualization]]
* [[Cloud Computing]]
* [[Botox-an invasive medical application]]
|-
! style="background:lightgrey" valign=top colspan=2 |

===Finance===
|-
| valign=top colspan=2 |
* [[Innovative personal finance products]]
* [[Life Insurance Industry in US]]
|}

== Dolcera Technology Platform ==
{| style="border:1px solid #AAA; background:#E9E9E9;width:100%" align="center"
|-
| align = "top" |
==== IP and Products dashboard ====
* [http://client.dolcera.com/dashboard/dashboard.html?workfilegroup_id=10 Alopecia areata dashboard]
* [http://www.dolcera.com/ipmapdemo/stent_model.swf Stent dashboard]
* [[Legal Updates Demo|Legal updates dashboard]]
* [http://client.dolcera.com/dashboard/dashboard.html?workfile_id=54 4G wireless product and patent dashboard]

==== Patent-pathway mapping ====
* [[Inflammation and cardiovascular drugs#Interactive signaling pathways and patents|Patent-pathway mapping]]
==== Sequence dashboard ====
* [http://www.dolcera.com/website/demos/dna/main.html Sequence dashboard]

==== Design analysis ====
* [http://www.dolcera.com/website/demos/dental/main.html Dental Implant Design Analysis]

==== Innovation explorer ====
* [http://www.dolcera.com/ipmapdemo/innovation_explorer/innovation_explorer.html Household robotics innovation explorer]
==== KPort ====
* [http://dolcera.com/website/demos/kport/main.html Collaboration Portal]

|-
|}

=== Dolcera Offerings summary ===
* [[Dolcera Offerings|Dolcera offerings summary]]

==Like any of these sample reports?==
 '''These are sample reports with brief analysis''' 
'''Dolcera can provide a comprehensive report customized to your needs'''
{|border="2" cellspacing="0" cellpadding="4" align="center" "
|style="background:lightgrey" align = "center" colspan = "3"|'''[mailto:info@dolcera.com Buy the customized report from Dolcera]'''
|-
| align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services Patent Analytics Services]
|align = "center"| [http://www.dolcera.com/website_prod/services/business-research-services Market Research Services]
|align = "center"| [http://www.dolcera.com/website_prod/tools/patent-dashboard Purchase Patent Dashboard]
|-
|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Landscape Services]
|align = "center"| [http://www.dolcera.com/website_prod/research-processes Dolcera Processes]
|align = "center"| [http://www.dolcera.com/website_prod/industries Industry Focus]
|-
|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Search Services]
|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/alerts-and-updates Patent Alerting Services]
|align = "center"| [http://www.dolcera.com/website_prod/tools Dolcera Tools]
|-
|}
 
----
{| style="border:1px solid #AAA; background:#E9E9E9" align="center"
|-
! style="background:lightgrey" | Contact Dolcera
|-
! style="background:lightgrey" | Samir Raiyani
|-
| '''Email''': [mailto:info@dolcera.com info@dolcera.com]
|-
| '''Phone''': +1-650-269-7952, +91-40-2355-3493
|}