View source for BIOSIS / 2001:508352

AN   
     2001:508352  BIOSIS
DN   
     PREV200100508352
TI   
     A common hormone-sensitive lipase i6 gene polymorphism is associated
     with decreased human adipocyte lipolytic function. 
AU   
     Hoffstedt, Johan [Reprint author]; Arner, Peter; Schalling, Martin;
     Pedersen, Nancy L.; Sengul, Selim; Ahlberg, Susanne; Iliadou, Anastasia;
     Lavebratt, Catharina
CS   
     Karolinska Institutet, Huddinge University Hospital, CME, M61, 141 86,
     Stockholm, Sweden
     johan.hoffstedt@medhs.ki.se
SO   
     Diabetes, (October, 2001) Vol. 50, No. 10, pp. 2410-2413. print. 
     CODEN: DIAEAZ. ISSN: 0012-1797. 
DT   
     Article
LA   
     English
ED   
     Entered STN: 31 Oct 2001
     Last Updated on STN: 23 Feb 2002
AB   
     Hereditary factors may be involved in the pathogenesis of type 2
     diabetes.  A polymorphism in the hormone-sensitive lipase (HSL)
     gene (HSLi6) is associated with obesity and diabetes, although it is
     unknown whether the polymorphism is functional and thereby influences
     lipolysis.  We genotyped 355 apparently healthy non-obese male and female
     subjects for the HSLi6 polymorphism.  Allele 5 was found to be the most
     common allele (allele frequency 0.57).  In 117 of the subjects, we
     measured abdominal subcutaneous fat cell lipolysis induced by drugs acting
     at various steps in the lipolytic cascade.  The lipolysis rate induced by
     norepinephrine isoprenaline (acting on beta-adrenoceptors), forskolin
     (acting on adenylyl cyclase), and dibutyryl cyclic AMP (acting on HSL)
     were all decreased by apprx50% in allele 5 homozygotes, as compared with
     noncarriers.  Heterozygotes showed an intermediate lipolytic rate.  The
     difference in lipolysis rate between genotypes was more pronounced in men
     than in women.  We conclude that allele 5 of the HSLi6 polymorphism is
     associated with a marked decrease in the lipolytic rate of abdominal fat
     cells.  This may in turn contribute to the development of obesity.
CC   
     Genetics - Human   03508
     Metabolism - General metabolism and metabolic pathways   13002
     Metabolism - Metabolic disorders   13020
     Endocrine - General   17002
IT   
     Major Concepts
        Clinical Endocrinology (Human Medicine, Medical Sciences); Medical
        Genetics (Allied Medical Sciences); Metabolism
IT   
     Diseases
        obesity: nutritional disease
        Obesity (MeSH)
IT   
     Diseases
        type II diabetes: metabolic disease
        Diabetes Mellitus, Non-Insulin-Dependent (MeSH)
IT   
     Miscellaneous Descriptors
        lipolysis
ORGN 
     Classifier
        Hominidae   86215
     Super Taxa
        Primates; Mammalia; Vertebrata; Chordata; Animalia
     Organism Name
        human: female, male, patient
     Taxa Notes
        Animals, Chordates, Humans, Mammals, Primates, Vertebrates
GEN  
     human HSL gene [human hormone-sensitive lipase gene] (Hominidae)