View source for BIOSIS / 2004:316145

AN   
     2004:316145  BIOSIS
DN   
     PREV200400316750
TI   
     In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of
     hormone-sensitive lipase. 
AU   
     Lowe, Derek B. [Reprint Author]; Magnuson, Steven; Qi, Ning; Campbell,
     Ann-Marie; Cook, James; Hong, Zhenqiu; Wang, Ming; Rodriguez, Mareli;
     Achebe, Furahi; Kluender, Harold; Wong, Wai C.; Bullock, William H.;
     Salhanick, Arthur I.; Witman-Jones, Terri; Bowling, Mary E.; Keiper,
     Christine; Clairmont, Kevin B.
CS   
     Dept Chem, Bayer Res Ctr, 400 Morgan Lane, W Haven, CT, 06516, USA
     derek.lowe.b@bayer.com
SO   
     Bioorganic & Medicinal Chemistry Letters, (June 21 2004) Vol. 14, No. 12,
     pp. 3155-3159. print. 
     CODEN: BMCLE8. ISSN: 0960-894X. 
DT   
     Article
LA   
     English
ED   
     Entered STN: 15 Jul 2004
     Last Updated on STN: 15 Jul 2004
AB   
     A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar
     inhibitors of hormone-sensitive lipase, an enzyme of potential
     importance in the treatment of diabetes.  Copyright 2004 Elsevier Ltd.
     All rights reserved.
CC   
     Pathology - Therapy   12512
     Metabolism - Metabolic disorders   13020
     Endocrine - Pancreas   17008
     Pharmacology - General   22002
IT   
     Major Concepts
        Pharmacology
IT   
     Diseases
        diabetes: endocrine disease/pancreas, metabolic disease
        Diabetes Mellitus (MeSH)
IT   
     Chemicals & Biochemicals
        (5-(2H)-isoxazolonyl) ureas: hormone-sensitive lipase inhibitors,
        in vitro structure-activity relationships; hormone-sensitive lipase
IT   
     Miscellaneous Descriptors
        lipolysis
RN   
     9001-62-1 (hormone-sensitive lipase)