https://www.dolcera.com/wiki/index.php?action=history&feed=atom&title=BIOSIS_%2F_2004%3A256580 2026-05-01T12:53:09Z Revision history for this page on the wiki MediaWiki 1.24wmf12 https://www.dolcera.com/wiki/index.php?title=BIOSIS_/_2004:256580&diff=5110&oldid=prev 2008-08-22T05:36:44Z

<p></p> <p><b>New page</b></p><div>AN <br /> 2004:256580 BIOSIS<br /> DN <br /> PREV200400256670<br /> TI <br /> Carbazates as potent inhibitors of hormone-sensitive lipase. <br /> AU <br /> de Jong, Johannes C.; Sorensen, Lotte G.; Tornqvist, Hans; Jacobsen, Poul<br /> [Reprint Author]<br /> CS <br /> Medicinal Chemistry, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev,<br /> Denmark<br /> pjac@novonordisk.com<br /> SO <br /> Bioorganic &amp; Medicinal Chemistry Letters, (5 April 2004) Vol. 14, No. 7,<br /> pp. 1741-1744. print. <br /> CODEN: BMCLE8. ISSN: 0960-894X. <br /> DT <br /> Article<br /> LA <br /> English<br /> ED <br /> Entered STN: 12 May 2004<br /> Last Updated on STN: 12 May 2004<br /> AB <br /> The central role of adipose tissue hormone-sensitive lipase in<br /> regulating fatty acid metabolism makes it a potential pharmacological<br /> target for the prevention of peripheral insulin resistance in obese,<br /> prediabetic and diabetic individuals. The synthesis of a new series of<br /> carbazates is presented. Modification of the phenolic 4-position in a<br /> series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived<br /> carbazates, yielded inhibitors of the catalytic activity of this enzyme<br /> with nanomolar potency.<br /> CC <br /> Biochemistry studies - General 10060<br /> Biochemistry studies - Lipids 10066<br /> Enzymes - General and comparative studies: coenzymes 10802<br /> Pathology - Therapy 12512<br /> Metabolism - General metabolism and metabolic pathways 13002<br /> Metabolism - Metabolic disorders 13020<br /> Endocrine - Pancreas 17008<br /> Pharmacology - General 22002<br /> IT <br /> Major Concepts<br /> Enzymology (Biochemistry and Molecular Biophysics); Pharmacology<br /> IT <br /> Parts, Structures, &amp; Systems of Organisms<br /> adipose tissue<br /> IT <br /> Diseases<br /> diabetes: endocrine disease/pancreas, metabolic disease, drug therapy<br /> Diabetes Mellitus (MeSH)<br /> IT <br /> Diseases<br /> obesity: nutritional disease<br /> Obesity (MeSH)<br /> IT <br /> Chemicals &amp; Biochemicals<br /> 1,2,3,4-tetrahydroisoquinoline; carbazates: enzyme inhibitor-drug;<br /> fatty acid: metabolism; hormone-sensitive lipase: inhibition; morphine<br /> IT <br /> Miscellaneous Descriptors<br /> peripheral insulin resistance<br /> RN <br /> 91-21-4 (1,2,3,4-tetrahydroisoquinoline)<br /> 9001-62-1 (hormone-sensitive lipase)<br /> 57-27-2 (morphine)</div>

Admin