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<p></p> <p><b>New page</b></p><div>AN <br /> 2004:316145 BIOSIS<br /> DN <br /> PREV200400316750<br /> TI <br /> In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of<br /> hormone-sensitive lipase. <br /> AU <br /> Lowe, Derek B. [Reprint Author]; Magnuson, Steven; Qi, Ning; Campbell,<br /> Ann-Marie; Cook, James; Hong, Zhenqiu; Wang, Ming; Rodriguez, Mareli;<br /> Achebe, Furahi; Kluender, Harold; Wong, Wai C.; Bullock, William H.;<br /> Salhanick, Arthur I.; Witman-Jones, Terri; Bowling, Mary E.; Keiper,<br /> Christine; Clairmont, Kevin B.<br /> CS <br /> Dept Chem, Bayer Res Ctr, 400 Morgan Lane, W Haven, CT, 06516, USA<br /> derek.lowe.b@bayer.com<br /> SO <br /> Bioorganic &amp; Medicinal Chemistry Letters, (June 21 2004) Vol. 14, No. 12,<br /> pp. 3155-3159. print. <br /> CODEN: BMCLE8. ISSN: 0960-894X. <br /> DT <br /> Article<br /> LA <br /> English<br /> ED <br /> Entered STN: 15 Jul 2004<br /> Last Updated on STN: 15 Jul 2004<br /> AB <br /> A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar<br /> inhibitors of hormone-sensitive lipase, an enzyme of potential<br /> importance in the treatment of diabetes. Copyright 2004 Elsevier Ltd.<br /> All rights reserved.<br /> CC <br /> Pathology - Therapy 12512<br /> Metabolism - Metabolic disorders 13020<br /> Endocrine - Pancreas 17008<br /> Pharmacology - General 22002<br /> IT <br /> Major Concepts<br /> Pharmacology<br /> IT <br /> Diseases<br /> diabetes: endocrine disease/pancreas, metabolic disease<br /> Diabetes Mellitus (MeSH)<br /> IT <br /> Chemicals &amp; Biochemicals<br /> (5-(2H)-isoxazolonyl) ureas: hormone-sensitive lipase inhibitors,<br /> in vitro structure-activity relationships; hormone-sensitive lipase<br /> IT <br /> Miscellaneous Descriptors<br /> lipolysis<br /> RN <br /> 9001-62-1 (hormone-sensitive lipase)</div>

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